Job Description

Details:

• Pay for this position is 62.00 to 67.00 hourly depending on experience.
• This position is a one-year contract with the possibility of extension or conversion to permanent.
• Location: South San Francisco, CA. Local candidates only.

Qualifications:

• Master's degree with 1-3 years of industry experience, OR Bachelor's degree in with 3+ years of industry experience.
• Expertise in mammalian cell culture (suspension and adherent cell lines, primary T cells preferred) and multi-color flow cytometry (panel design, acquisition, and analysis using FlowJo) is required.
• Hands-on experience with immunological assays (e.g., ELISA, Luminex, cytotoxicity) is highly desirable.
• Experience with semi-automated liquid handling systems for high-throughput workflows is highly preferred.
• Familiarity with data analysis tools (e.g., GraphPad Prism, FlowJo) is required; working knowledge with statistical and bioinformatics tools (python, R, etc.) is a plus.
• Basic understanding of immunology, cancer biology, or cell therapy applications is preferred; Prior experience in genetic medicine, CAR-T cell therapy, or RNA therapeutics is a strong plus.
• Basic knowledge of nucleic acid characterization (e.g., gel electrophoresis, qPCR), familiarity with molecular biology techniques, including cloning (e.g., Gibson assembly, PCR) and mRNA IVT (e.g., capping, purification), is a strong plus.

Key Responsibilities:

• Design and perform plate-based and cell-based assays (multi-color flow cytometry, Western blot, ELISA, etc.) to assess mRNA delivery and protein expression in mammalian cells using LNP systems.
• Design and perform high-throughput expression and functional screen/characterization assays for Client protein/mRNA candidates, using semi-automated instruments.
• Maintain meticulous records in an electronic lab notebook (ELN), draft standard operating procedures (SOPs), and present results at team meetings.
• Independently plan, execute, and interpret experiments, delivering data-driven insights aligned with project timelines and goals.
• Conduct molecular biology tasks, including cloning (e.g., PCR, golden gate, Gibson reactions, etc.), and optimize mRNA IVT protocols for yield and quality.

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